An administrative core will carry out functions that interface with the 3 projects and with the 3 scientific cores. The administrative core will include Dr. Jeffrey V. Ravetch as Core Leader and his Laboratory Administrator as well as the Administrative Assistant in the laboratory of Dr. Ralph Steinman. The Laboratory Administrator and Administrative Assistant will function to: arrange meetings among investigators;prepare protocol submissions and annual renewals to the Institutional Review Boards;arrange contacts and prepare reports;help to prepare, submit and track manuscripts;monitor budgets and manage personnel including immigration, stipends, benefits and housing.